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Aquaculture diversification entails new challenges during early life stages of candidate species such as survival bottlenecks or body malformations, many of them due to uncoupling between classic diets and early nutritional requirements.
Thus, we hypothesized that Sirt4 deficiency leads to an ANT2-dependent increase in respiration due to uncoupling.
The mechanism of tolcapone-induced hepatoxicity is not known but may relate to abnormalities in mitochondrial respiration in hepatocytes due to uncoupling of oxidative phosphorylation.
Sometimes free radicals are generated due to uncoupling of oxidative phosphorylation and diversion of electrons from the respiratory electron transport chain [ 45, 46].
As shown above, it was evident that the decrease in the Tin response was not due to uncoupling of the IP3/Ca2+-release system since the oscillatory responses in all the oocyte groups remained unchanged.
Importantly, these mutants retained sensitivity to pHo inhibition and support the idea that the absence of responses to membrane potential changes was not caused by malfunctioning C-type gate, but rather due to uncoupling of Ct from the pore.
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Oxidative stress due to uncoupled NOS activity in turn leads to oxidation of BH4 to BH2 and further propagation of NOS uncoupling.
Published: November 25, 2015 Brown adipose tissue (BAT) is responsible for heat generation, a process that occurs due to the uncoupling of electron transport from ATP synthesis by uncoupling protein 1 (UCP1).
This has exacerbated environmental degradation due to the uncoupling of carbon (C) and N cycles in agroecosystems.
BAT is therefore highly metabolically active due to the uncoupling of electron transport from ATP production in the inner mitochondrial membrane, allowing for active substrate oxidation and a low rate of ATP production with heat generation instead.
Decreased ∆Ψm, due to the uncoupling of electron flow from ATP synthesis by increased proton permeability of the inner mitochondrial membrane, can reduce ROS production at complex I by decreasing NAD(P H/NAD(P)+ and possibly by decreasing the life span of the semiquinone radical [39].
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