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The remaining one third of patients would have had their procedure postponed for a variable duration, either due to the wait for an anesthetist to arrive or the time needed to attempt transfer of the patient to another facility, which may occur with significant delay and difficulty.
Due to the wait, however, Maillet had gone ahead nine months prior to his appointment and paid for his own double mastectomy, a procedure needed due to the side effect of painful breast development from his prescribed hormone regiment.
The trial was limited to a three month data collection phase due to the wait list design, ethical constraints and restrictions on research funding.
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Systems that do not employ scheduling may feature longer waiting periods for tasks moreover, some short-term tasks may terminate, due to the waiting period.
Blinding is not possible for the HARMONY Study due to the wait-list control design of the study.
The Project Co-ordinator is not blinded to group allocation and participant blinding is not possible due to the wait-list control design of the trial.
In particular, we observed that the exponential growth is dominated by the fittest possible mutant, but there is a correction of log n to this growth rate due to the waiting time associated with producing a maximally fit mutant.
8 Access to this form of therapy may be particularly useful for patients requiring low-intensity therapy and for those who find it difficult to seek help from a therapist due to the waiting time or fear stigmatisation.
However, genetic changes from standing variation as opposed to new mutations are likely to be essential for adaptation during invasion, due to the waiting time required for new mutations (Barrett and Schluter 2008; Prentis et al. 2008).
As the impact of the time waited depends on the level of need, the measure of results used as the main outcome was waiting time weighted by priority score, which can be interpreted as the time that a patient waits, due to the waiting list, weighted by his/her need for surgery.
However it appears that the wait-list control group was not acceptable to many participants due to the long wait before attending, or difficulty attending on the specific dates (e.g., due to pre-planned holidays), or due to a change in their circumstances (e.g., return to work).
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