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This result confirmed that the antibacterial activity also depended on the size, and it was probably due to the internalization and subsequent accumulation of NPs inside the cells until the particles reached the cytoplasmic region.
In case efficiencies are present, it is possible to disentangle the effect of the increase in prices due to the internalization of competition between the merging firms and the effect of the synergies.
Furthermore, attesting low cytotoxicity and highlighting the biocompatibility of Au-CSCaCO3NPs and potential usefulness for biomedical applications, the cytotoxicity could be due to the internalization of the nanoparticles which possibly triggered intracellular responses and thus induced cellular damage because of interaction with cell organelles.
However following ligand entry, the signal in the cytoplasm is increased and is detectable at the experimental intensity due to the internalization of the ligand-surface nucleolin complex.
It may be due to the internalization of accumulated L1-CAM by the antibody binding as demonstrated in vitro (Schmid et al., 2000).
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The higher cytotoxicity potential of CChSLN was due to the better internalization in the cancer cells and controlled release of encapsulated component in comparison with CSLN.
This could be due to the higher internalization of the drug-loaded nanoparticles inside the cells, which leads to the combined effect of apoptosis and necrosis events.
Due to the enhanced internalization efficiency of the EuE-based inhibitors, markedly higher uptake in tumor lesions was observed compared to 18F-DCFPyl and 18F-PSMA-1007.
The superior cytotoxic effect of FPCC could be attributed due to the higher internalization of FPCC inside the cells (due to the surface modification of folic acid) and continuous exposure and sustained release of the drug for a prolonged period of time at the site of action.
However, due to the known internalization of the used antibodies that subsequently lowers the surface-residing fraction available for the IEDDA reaction, time points earlier than 72 h were also investigated in the pretargeting experiment in order to attain optimal balance between the amount of surface-bound and freely circulating mAb.
We note that in contrary to B, the total level of receptor does not increase in the region of cooperation (around point I in Figure 3A), due to the different internalization times of the unbound and bound receptor.
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