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The cardinal symptom of ALS patients is muscle atrophy due to the dysfunction of motor neurons (Al-Chalabi and Hardiman, 2013).
This chronic activation is probably due to the dysfunction of negative regulation and T cells; Finally, the process also activates fibroblasts, with production of collagen, and myofibroblasts, which promote capsular contracture [6, 8].
Taken together, the data present novel evidence that oxidative stress in CF epithelia is not resolved through the ARE due to the dysfunction of Nrf-2.
Furthermore, the surfactant production is also decreased due to the dysfunction of type II epithelial cells.
This could be due to the dysfunction of WWOX, that is, its impact on apoptosis.
The most common symptom of Cu toxicity in plants is chlorosis of vegetative tissues due to the dysfunction of photosynthesis [ 4].
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Such diseases arise due to the dysfunctioning of fundamental homeostatic regulatory mechanism that governs mammary gland development and function.
Heart failure is the leading cause of death in the Western world and is rapidly increasing worldwide [ 1– 3], and it occurs due to the dysfunction or loss of cardiomyocytes [ 4].
As the crises of the transition have mounted, the momentum of the revolution has been lost, not just due to the disunity and dysfunction of the revolutionaries, but as a result of a widespread loss of perspective about the revolution and its aftermath.
The effect of androgen excess on body iron stores might result from the well-known stimulatory effect of androgens on erythropoiesis, thereby increasing intestinal iron absorption (24) but may also result from the iron-sparing effect of reduced menstrual losses due to the chronic menstrual dysfunction of PCOS.
The high recurrence rate is due to the long-lasting dysfunction of the eustachian tube and the immune immaturity of children less than 2 years of age.
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