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Due to the desirability of reclaiming the AICAR, we expect to find at least the final two steps of the de novo purine pathway present whenever the histidine biosynthesis pathway is present.
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The sensitive nature of the questions (related to sexual and drug use behaviors) may have led to information bias due to the social desirability of certain answers.
This is partly due to the social desirability bias, which is consistent with the ceiling effect observed for the EDSQ self-declared compliance score in our study.
Since our study relies on self-reports obtained from adolescents via a questionnaire for data collection, there is a risk that the actual prevalence of smoking may be different from the reported prevalence, for example, due to the social desirability bias.
Why our results run counter to what has been observed in the literature is unclear, but it could be due to the role social desirability may or may not play in the accuracy of self-reported CRC screening.
Finally, we may expect some measurement bias to persist due to the influence of social desirability on reporting.
The low predictive value of the variables involved may be a consequence of a reduced variance due to the effect of social desirability.
Another limitation of the study could be that sensitive questions regarding sexual behaviors might have been underreported, due to the issue of social desirability.
For example, in the GUI cohort, women may have under-reported to a greater extent due to the influence of social desirability in the presence of a trained government interviewer.
21 Some under-reporting of alcohol consumption is known to exist due to the pressure of social desirability and recall error, but self-reported measures are nevertheless believed to have some validity.
Fourth, all of the information collected in our study was based on the self-report, and possible information bias may exist in our study, due to the problem of social desirability.
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