Due to sample size considerations, we restricted the number of independent variables to six factors.
Due to sample size considerations, we had to limit the number of independent variables; our multivariate analyses might therefore have missed relevant confounders.
Another limitation to our analysis is that due to sample size considerations we did not evaluate interaction effects, for example anemia and chronic kidney disease.
We chose not to evaluate adjusted mortality based on the appropriateness of treatment due to sample size considerations in the context of the low percentage of patients with evidence of appropriate treatment.
Due to sample size considerations, sensitivity analyses were not performed based on reasons for discontinuation of the prior anti-TNF agent, although other studies have shown that this can influence treatment response [ 10].
It also included the self-rated health and self-rated mental health questions, both measured on a 5-point Likert scale (very good, good, fair, poor, very poor); due to sample size considerations, both variables were dichotomized in the analysis into very good, good, and fair versus poor and very poor.
Numbers rounded to the nearest 100 due to sampling methodology.
Growth profile differences could also be due to sample heterogeneity; further consideration of in vitro growth parameters is necessary [ 32].
Correlation analyses were also performed in an exploratory manner due to sample size and composition considerations.
The differences between studies may be due to sample size, different correlations between hormones examined or, in our study, consideration of multiple estrogen and androgens simultaneously.
First, the participants were chosen according to convenience sampling due to feasibility considerations.
