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The number of months of regimens dispensed was used in the calculation of HAART costs to allow for possible wastage due to regimen switching.
This pattern could be due to regimen complexity and burden in terms of multiple daily injections, regimen-related psychological distress, and other psychological impacts of requiring insulin (9, 12).
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Despite the increased intensity of this regimen, mortality due to regimen-related toxicity (RRT) was improved compared to other high-intensity regimens in the literature and is reflected in the 7% 100-day TRM.
High intensity regimens, while improving relapse rates, tend to offset this gain with an increased transplant-related mortality (TRM) due to regimen-related toxicity, tissue damage and increased incidence and/or severity of graft-versus-host disease (GVHD).
There is an asymmetry due to regimens being defined by CD4 counts dropping below a threshold.
The median days to regimen modification due to lipodystrophy was longest while rash-related regimen modification occurred earliest.
In this study, time to regimen modification due to lipodystrophy was around three times longer than other studies [ 5, 6].
Possibly due to this regimen, blood inflammatory markers temporarily decreased significantly and a fever-free interval was achieved.
All analyses were stratified by receipt of oxytocin prophylaxis in order to adjust for heterogeneity that may have been due to clinical regimen.
Increasing comorbidities are associated with an increase in polypharmacy (taking more than five medications) [ 7], which may worsen medication adherence due to increased regimen complexity or "pill fatigue".
The difference between these findings might be attributed to the differences in patients' characteristics or might be due to treatment regimen undertaken; though, in both studies patients did not receive neoadjuvant treatment.
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