Sentence examples for due to receptor binding from inspiring English sources

The present work suggests that peptide drug conjugate conformation change due to receptor binding may be a viable approach to targeted drug release.

The significant increases in t1/2 values due to receptor binding were observed for three histidine residues, His263, His304, and His336, suggesting that their solvent accessibilities decreased upon receptor binding.

In addition, a reduced receptor binding may be due to receptor down-regulation, internalized (non-available if not immediately recycled) (Fig. 3D) receptors or a pathological change due for example, to neuronal damage or neurodegeneration.

Hsu and colleagues reported that the presence of RIP2 enhances the interaction between NOD2 and CARD9 [17].This could be through promotion of conformational changes due to receptor activation which expose the CARD9 binding motifs on NOD2; or by promoting protein clustering and thereby increasing the avidity of the NOD2 CARD9 interaction.

The precision is due to receptor molecules, which are activated following their recognition and binding of specific neurotransmitters.

The lipid transporting and catabolic activity in APOE- ε2 carriers is significantly slower as compared to ε3 and ε4 carriers due to lowest receptor binding affinity of ε2.

IL-8 is not to be determined at significant concentrations in plasma due to its receptor binding but may play a major role in tissues.

Although we have not yet parsed the degree to which behavioral changes in humanized animals are due to altered receptor binding affinities, expression levels and/or distribution patterns, this model might serve as a useful investigatory preclinical tool, while providing opportunities for further dissection of the social behavior neural network.

As a result, it may be possible that the ability of the vasculature to support tissue growth may be dictated by VEGFR2 activation at the vessel itself, due to the receptor binding behavior of soluble VEGF, as suggested in numerous studies [ 16, 17].

In parallel studies, the specific cell uptake due to σ receptor binding was verified by the presence of a variety of σ ligands including -pentazocine (σ1), haloperidol (non-selective σ1/σ2) and unlabelled SIG343 and SIG353 (σ2).

[dY]KP-10 had a lower affinity for the human KISS1R in vitro, suggesting that its increased effects may not be due to improved receptor binding.