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This study established a new successful approach to increasing ethanol production from glucose in S. cerevisiae by homologous overexpression of PHO8 gene due to multiple genomic insertion events.
Several evidences depict that the expressions of miRNAs are remarkably modulated in malignant tissues due to multiple genomic and epigenetic alterations.
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There are usually multiple versions of custom CDFs for one platform due to multiple genome databases.
† Species identity not determined due to multiple genetic matches.
However, each may be prone to false positive/negative findings, partially due to multiple testing in genomic approaches, statistical power (partially associated with conservative procedures accounting for multiple testing), and the biological complexity of gene expression and genetic etiology.
Third, increasing evidence shows that the expression of miRNAs is remarkably deregulated in cancer due to multiple epigenetic and genomic alterations.
A drawback of the CAGE approach thus far has been the removal of as many as 40% of CAGE sequence tags due to their mapping to multiple genomic locations.
At least half of the 37 trans eGenes appeared to be long-range cis associations (>500 kb), and several appeared to be possible misinterpretations due to genes that map to multiple genomic locations.
Another 7% of reads were mapped to multiple genomic locations, possibly due to repetitive regions in the human genome.
The most common reasons why hits between a genomic segment and an orthologous protein were rejected were: - Segments did not contain an intact ORF, due to multiple stop codons and/or frameshifts.
PRS analysis allows for more genetic information to be assessed from genomic data than a simple threshold approach, such as the GWAS threshold, which conventionally uses a p-value threshold of 5 × 10− 8 to avoid issues of false positive findings due to multiple testing.
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