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However, the delivery of curcumin is hindered due to low solubility and poor permeation.
Downward migration of DNAPL can lead to formation of impermeable strata due to low solubility and high density.
Supposedly due to low solubility in the crystallisation buffer, in both structures the inhibitor shows reduced occupancy of 74% and 46% population, respectively.
Paclitaxel (PTX) is a potent anticancer drug which suffers limitations of extremely low oral bioavailability due to low solubility, rapid metabolism and efflux by P-gp transporters.
Additionally, nonaqueous flow batteries could leverage new redox couples that are incompatible with aqueous electrolytes due to low solubility, chemical reactivity, and redox potentials outside of the aqueous stability window.
The activity of water in liquid phase is presumed to be unit due to low solubility of methane in water.
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Due to low solubilities of vanillic, 4-hydroxybenzoic, and 4-hydroxycinnamic (ρ-coumaric) acids, concentrations causing more than 50% inhibition were not tested; therefore MICs were extrapolated from the inhibition curves.
This offers new life to bioactive compounds abandoned due to low aqueous solubility.
So, due to low water solubility but high therapeutic value we hereby try to synthesize the glucosyl analogues of epothilone A using in vitro glycosylation approach.
In some cases due to low protein solubility, cultures were scaled to 2 L and growth was performed at 28°C.
Its systemic bioavailability is less than 8% due to low aqueous solubility (0.3 ± 0.02 μg/mL) [ 3, 6– 8].
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