Sentence examples for due to locus from inspiring English sources

These results were strongest in families not previously screened for linkage, and simulation studies suggest that these findings are likely due to locus heterogeneity rather than random statistical error.

Due to locus heterogeneity of 3-methylglutaconic acidurias, a SNP array was performed revealing 261 Mb of ROHs > 8 Mb (374 Mb of ROHs > 1 Mb).

The contribution of SNPs to the familial risk of PrCa, under a multiplicative model, was computed using the formula ∑ k log λ k log λ 0, where λ 0 is the observed familial risk to first-degree relatives of PrCa cases, assumed to be 2 (47, 47), and λ k is the FRR due to locus k.

Instead, it seems likely that the bulk of genetic variance underlying diseases is due to loci where susceptibility mutations are mildly deleterious and where there is a high overall mutation rate to the susceptible class.

Alternatively, using simple demographic models, likelihood-based approaches allowing a full use of the information contained in the data sets have also been developed to distinguish, among the evolutionary forces shaping differences in allele frequency, those pertaining to population-specific factors (e.g. migration or drift) from those due to locus-specific factors (such as selection).

This distortion could be due to inadvertent selection of the lines in this mapping population, biases in genotyping error, and/or due to loci containing underlying sterility or incompatibility factors [24] [27].

An alternative approach to the detection of selection signatures is based on the measure of population differentiation due to locus-specific allele frequencies between populations, which is quantified using the FST statistic [ 12].

The fact that only a minority of surveyed loci revealed deviations from HWE indicates that the investigated population overall is in Hardy-Weinberg equilibrium, and that deviations at individual loci are most likely due to locus-specific effects, and not due to biological factors such as inbreeding or genetic drift, which would affect all loci.

To address whether the aforementioned response is due to locus-specific functions of ORC1/CDC6 or reflects a genome-wide influence on gene expression, we used RNA sequencing (RNAseq) to compare mRNA abundance in PCF Lister 427 cells 96 hr post-RNAi induction relative to uninduced cells.

This was due to loci not amplifying in the focal species as well as their discontinued use due to lack of polymorphism.

We also expect that most of the change in phenotype will be due to loci that have not yet fixed the favorable allele.