Thus, our data present essential new information possibly related to prion pathogenesis in which a functional synaptic role of PrPC is compromised due to its advanced conversion into PrPSC thereby creating a lack-of-function scenario.
However, at the highest cycloheximide dose, hepatocyte viability may have been compromised due to its general toxicity, even though we did not observe significant hepatocyte loss based on nucleus counts.
We speculated that neurogenesis may be compromised in this strain due to its depressive phenotype and concurrent BDNF downregulation.
His friends speculate that in addition to drugs, he may have contracted an illness that his body could not fight off, due to a compromised immune system.
Due to their compromised immune statuses, clinical, laboratory and molecular signs for infection are often subtle and nonspecific.
40 of 43 procedures were classified as R0 resections; 1 CHS grade-2 periacetabular resection had R1 margins due to a compromised soft-tissue margin, 1 CHS grade-1B proximal tibia had R1 margins due to a compromised bone margin, and 1 pelvic CHS grade-2A had an R2 resection also due to compromised bone margins.
Alternatively, these effects could be due to compromised iron acquisition in neuromelanin cells, which may disrupt dopaminergic mechanisms (Stiasny-Kolster et al. 2004c).
Nevertheless, these data are consistent with the observation in aging people, where AMPK basal activity was enhanced [ 32], due to compromised cellular energetics [ 33].
Period lengthening has previously been demonstrated in PER2::LUC colon explants and is probably due to compromised tissue viability ex vivo (Malloy et al., 2012).
