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This pressure in addition to possible changes in recombination, due to improper function of nuclear gene(s) such as MSH1 and RECA3[ 41] that control recombination in the mitochondrial genome, can lead to high frequency of heteroplasmy.
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Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the legs.
However, asthma control in many patients is suboptimal, due to improper use of asthma medications and non-adherence.
Drug resistance arises due to improper use of antibiotics in chemotherapy of drug susceptible organisms [ 6].
These participants had a high risk of acquiring HCV infection due to improper use of needles and syringes.
The examples we provide include diseases caused by loss-of-function mutations (due to improper folding, degradation or localization) and diseases resulting from gain-of-function mechanisms (mutations that cause a toxic novel function, dominant-negative mutations and amyloid accumulation).
Major medical operations have become routine, much due to improper eating.
The disease etiology remains unclear; however, genetic evidence and experimental models suggest that intestinal cell death due to improper responses to endoplasmic reticulum (ER) stress leads to impaired barrier function (Kaser et al., 2008).
A part of loss circulation is due to improper selection of drilling parameters during operation.
Due to improper sanitation an epidemic has broken out and many children are sick.
Anchor bolts fail due to improper design or installation, improper maintenance and inadequate reinforcement.
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