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The amount of accumulated damage increases with age due to impairs in the DNA repair system and an intensified oxidative stress and decreased antioxidant defense [ 14].
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While it has been suggested that this DNA repair defect may be due to impaired nonhomologous end joining (NHEJ), the defect may also be due to impaired HR.
Hoshi, H. et al. Aldehyde‐stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.
Cancer cells are more susceptible to metabolic perturbations due to impaired electron transport chain (ETC) that promote uncontrolled proliferation.
Noninvasive evaluation of left ventricular ejection fraction is essential for identifying those at high risk due to impaired contractile function.
At 9 1/2 years of age, E-CPT testing clearly indicated that the PCB-related impulsive responding was due to impaired response inhibition and not impaired sustained attention.
This enhanced constriction to NE is not due to impaired endothelial cell release of nitric oxide or diminished smooth muscle response to nitric oxide.
This result suggests that the effects of PEG-HCCs on DTH are due to impaired T cell reactivation in situ, as found with some T lymphocyte-directed immunomodulators38, rather than homing inhibition as seen with other T cell immunomodulators42.
However, SAT/dSAT scores reflecting overall performance did not improve following proNGF blockade in trkA knockdown rats due to impaired performance in non-signal trials.
Conclusions: Deficient vitamin D levels may lead to increased mortality in individuals receiving ART and this relationship does not appear to be due to impaired CD4 T-cell reconstitution.
Although the majority of the research on HD focuses on free radical generation due to impaired electron transport chain functioning, the concept of free radical toxicity actually has its roots in inflammation biology.
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CEO of Professional Science Editing for Scientists @ prosciediting.com