Although this may be partly due to limitations in extrapolating pre-clinical data to patients, it may also be that there are significant constraints in the current clinical trials model that make it difficult to demonstrate efficacy.
This is likely to be mainly due to the need to extrapolate the data downstream of the last measured radial profile.
Due to strong limitations to extrapolate short-duration experiments to the preservation of biosisigatures on geological times, we discuss the possibility (or potential) of mineralized Yersinia intermedia MASE-LG-1 cells for further long-term fossilisation.
Furthermore, international challenges are important to make different approaches comparable and also provide a strong incentive for groups to enter a field [11], yet their performance results are difficult to extrapolate due to the relatively high homogeneity of training and test data within the competition.
These alterations suggest possible age-related dysfunction in PRRs responses; however, no clear consensus has been reached in defining age-related innate immune defects, in part due to the difficulty to extrapolate between mouse and human studies, the use of individual cell populations for analysis, and different age-related enrollment criteria used for subject selection.
Due to the difficulty of extrapolating this retrospective analysis directly to any recommendations for treatment, the results of this pilot study should be the basis for additional studies, including randomized trials to examine the efficacy and safety of rhTM for obstetric DIC.
A second potential source of bias may be related to the method used to extrapolate the OR due to the existence of potential heterogeneity.
It is difficult to believe that an electronic reminder had no effect, and this study did not manage to extrapolate this data due to a lack of respondents and of clarity concerning which vaccination the reminder addressed.
Our study found no significant association between history of fracture and T-score classification, although it is difficult to extrapolate to this population due to the variability in ambulatory status.
Animal studies have demonstrated the biological effects of PEDF on osteosarcoma; however, these results are difficult to extrapolate for human use due to the chosen study design and drug delivery methods.
