Your English writing platform
Discover LudwigSuggestions(1)
Exact(32)
Although radiosensitization effects were still observed, the underlying mechanism was found not due to dose enhancement, but rather the re-distribution of cell cycles to the radiosensitive G2/M phases by AuNPs.
Understanding that the compound being developed is dissolution limited due to dose and/or solubility typically requires conversion of the crystalline solid to that of a high energy amorphous solid or a cocrystal.
These studies are designed typically to determine toxicity-based maximum tolerated dose (MTD) without any consideration of changes in systemic dose due to dose nonproportionality and/or margin of exposure.
Only skin samples from female donors were utilized to avoid DNA methylation differences due to dose compensation of sex chromosomes [19].
These opposing effects could be due to dose differences.
There was no evidence of tumor regression due to dose escalation.
Similar(28)
However, the first-line treatment with curative intent is associated with considerable high toxicity due to dose-intense treatment strategies.
The true potential of cytokine therapies in cancer treatment is limited by the inability to deliver optimal concentrations into tumor sites due to dose-limiting systemic toxicities.
Moreover, with the aim to discriminate between tumour/metastases and surrounding tissue in the head and neck cancer region, renal uptake is of less concern for imaging of head and neck cancer, although it may limit the amount of activity that can be administered to patients due to dose-limiting toxicity to the kidneys.
55– 56 Due to dose-limiting toxicities of aminoglycosides, novel agents inducing readthrough have been sought.
However, they are weak PPARα agonists with limited efficacy due to dose-related AEs.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com