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The latter accounted for possible variations in baseline risk between studies due to differing methodological designs, study quality, populations, etc., and was assumed to be a fixed effect (herein, referred to as Model I, see Boreinsteign et al. [ 98]).
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It is well known that measurement properties of QoL questionnaires adapted for a different population may differ from their original version due to differing translational, cultural, and methodological factors [ 11, 21, 24].
We anticipate some methodological differences between the projects as we progress due to differing findings from early research stages and contextual differences between countries.
In this context, the prevalence rate of neurocognitive impairment in HIV infected patient differs substantially among studies due to different methodological approach and study population [ 17].
This is partly due to different methodological issues.
However, due to different methodological approaches, the cortisol values tend to vary.
The observations of differing cellular responses to proNGF could be due to differences in the mutated proNGF used or to methodological differences employed in the various studies.
Before conducting this meta-analysis, we hypothesized that the effect size may differ due to the methodological quality of the studies.
The slight difference is due to methodological differences.
The number of included studies differs widely across the reviews (3 144 studies) and appears to be largely due to differences in review focus (e.g., specific program type) and strictness of methodological inclusion criteria.
Higher heterogenicity due to methodological differences might explain the pronounced differences in HTN prevalence.
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