Sentence examples for due to dat from inspiring English sources

In OCT-3/DAT-IMAs, MPP+ efflux from cells that had accumulated very high concentrations of MPP+ due to DAT activity was observed (Fig. 1E).

Another significant difference between the Lammel and present studies is that their ratio variances were due to DAT expression differences, whereas ours are due to TH.

All 18 subjects who died with a dementia diagnosis were diagnosed as DAT probable and the 3 stable MCI and the single CN subject who converted to MCI were diagnosed as MCI due to DAT.

TBB (10 μM for 20 min) did not change the level of DAT available at the cell surface (hDAT surface expression for TBB exposure was 89.0 ± 12.9% of vehicle control; p > 0.40 by Student's t-test; n = 4), indicating that the reduced STX1/DAT interaction following CK2 inhibition is not due to DAT trafficking away from the plasma membrane.

It is possible that like MPP+, P+-MUS could be a dopamine transporter substrate and so can induce Parkinsonian syndromes due to DAT-mediated toxicity.

Increased vesicular depletion results in augmented cytoplasmic dopamine levels, which can then be moved into the extracellular space via DAT-mediated reverse transport more readily due to augmented DAT levels.

Instead, in our method, striatum changes due to decreased DaT density are observed from different points of view; MEU takes into account uptake changes, while DI detects dysmorphism in the ROI upon which this value is calculated.

In summary, our study of longitudinally assessed participants in ADNI who had biomarker and postmortem neuropathology found the clinical diagnosis of DAT and MCI due to AD was supported by a pathologic diagnosis of AD in all cases, although some cases had low burden of AD neuropathologic changes.

Given that DA transport efficiency by DAT is largely governed by surface DAT expression56, our results show that mutations of these residues do not alter either cell surface DAT expression or [3H]WIN35,428 binding sites in intact cells expressing these mutants, indicating that the altered Vmax in these mutants is not due to changing surface DAT expression.

To examine whether the reduced DA reuptake is due to loss of DAT protein in striatum, we examined the level of DATir by optical density in striatum in saline and METH -exposed and animals.

Due to limited resources, DAT was performed only with 13 positive samples and a similar number of negative samples.