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To check the influence of a potential bias in these results due to clusters of homologues in the set of 296 candidate genes, we manually eliminated all orthologues.
The lower limit of 1 kb is likely due to the windowing function of the MAT algorithm, while the larger SARs may be due to clusters of SARs, plasticity among cells, and/or association of highly transcribed genes with the nuclear scaffold (see below).
The level of HER2 amplification in tumors was classified as follows: low amplification (mean 7 10 signals per nucleus) or high amplification (mean >10 signals/nucleus or uncountable due to clusters of signals).
Twenty-one of the 51 tumors (41%) presented a low level of amplification (mean 7 10 signals per nucleus) and 30 tumors (59%) presented a high level of amplification (mean >10 signals/nucleus or uncountable due to clusters of signals indicating homogeneous staining regions).
In particular, according to recent studies (Table 2), both organizations reevaluated the role of tumor markers as an early warning able to highlight those patients at risk to have a recurrence due to clusters of tumor cells undetectable by conventional morphological imaging modalities.
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More sophisticated resolution of source apportionment is needed to fully capture water quality impairment due to clustering of STS along stream networks.
We have also investigated possible overestimation of effects due to clustering of neighboring outbreaks.
A comparably slower mobility in acrylamide gels was previously described for SPANX-A/D proteins [3], [6] and is likely due to clustering of charged amino acid residues.
As is frequently the case with spatial data, there was dependence in the geographic distance matrix due to clustering of the sample locations.
Multilevel analysis was used to address this dependency due to clustering of data.
Due to clustering of GPs, all subsequently referred patients will be in the same study group.
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