Sentence examples for due to apc from inspiring English sources

The 665 nm emissions are due to APC FRET and the 620 nm emissions are due to Eu-W1024 fluorescence.

There are recent reports of elevated rates of bleeding due to APC in clinical practice, particularly in patients with relative contraindications to the drug [ 2, 3].

We found that BCL9 is required for efficient β-catenin-mediated transcription in Wnt-stimulated HEK 293 cells, and in the SW480 colorectal cancer cell line whose Wnt pathway is active due to APC mutation.

Inhibition of the β-catenin pathway and c-Myc expression is a feature of FASN inhibition in cell lines with high constitutive TCF promoter activity due to APC or β-catenin mutations, and also in cell lines without these mutations that increase promoter activity in response to stimulation with exogenous Wnt3A.

Furthermore, the synthesized nanoparticles possessed a mesostructured characteristic due to leaving of APC organic components during final heat treatment.

However, premature death of these mice, due to loss of APC in other epithelia, prevented analysis of the role of Wnt signaling in TEC maintenance in adult mice [47].

Tumorigenesis due to mutations in APC is often attributed to deregulated β-catenin signalling.

Several defects observed in the SLE TCR signaling pathway are suggestive of an activation state and may be due to activation by APC and/or auto-antibodies.

In contrast, staining of Ctnnb1 in airway epithelial cells, mainly localized on apical cell membranes, was comparable between Apc CKO and WT lungs (Fig.  1d and Additional file 1), confirming mesenchymal specificity of altered Wnt signaling activity due to loss of Apc function.

As shown in Fig.  8d, both Ctnnb1/TCF consensus binding sites mentioned above have been shown to interact with Ctnnb1/TCF specifically, indicating that excessive expression of Vcan is mediated by hyperactivation of the Wnt/Ctnnb1 pathway due to loss of Apc inhibitory function.

The F5 rs6025 and F2 rs1799963 (commonly known as the factor V Leiden and the prothrombin G20210A polymorphisms, respectively) are well-established procoagulant polymorphisms that increase the risk of venous thrombosis, due to induction of APC resistance and increased levels of prothrombin, respectively.