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It is important to emphasize that we studied Cx26 not only for its short C-terminus, but also because genetic defects in the human gjbeta2 gene (Cx26) are the leading cause of the most common type of hereditary congenital hearing impairment due to altered structure that can prevent docking of hemichannels or alter trafficking of molecules through the channels.
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Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death.
Studies in GDF5-deficient mice have shown some anomalies in tendon formation, mainly due to altered collagen structure and excessive death through apoptosis of mesenchymal cells [ 76].
Therefore reduction of the H+/2e ratio (increased slippage) due to altered protein structures could be adaptive in low performance species.
However, older people are also more vulnerable in these settings due to altered family structures and living arrangements.
This protocol is innovative in specifically addressing threat perception and fear responses in individuals with dementia who are unlikely to have sufficient contextual or cognitive control over threat perceptions due to altered neurological structures and functions.
The proposal is based on the facts that 1) most eukaryotic proteins are localized to subcellular structures to perform their functions, 2) proteins may be directed to a different subcellular structure by a single amino acid change, and 3) proteins can have altered functions when relocalized due to altered microenvironments (Byun-McKay and Geeta 2007).
They explain that acquired perforating dermatosis (APD) is a rare disorder characterized by transepidermal elimination of contents from dermis with minimal disruption of surrounding structures, believed to be due to altered expression of dermal proteins.
Acquired perforating dermatosis (APD) is a rare disorder characterized by transepidermal elimination of contents from dermis with minimal disruption of surrounding structures, believed to be due to altered expression of dermal proteins.
Even though both the planktonic and biofilm cells were oxidizing lactate and reducing sulfate, the biofilm cells were physiologically distinct compared to planktonic growth states due to altered abundances of genes/proteins involved in carbon/energy flow and extracellular structures.
Microorganisms in biofilms are evidently less susceptible to antibiotics, importantly due to altered growth rate and delayed penetration of antimicrobial agents within the biofilm structure (Melchior et al. 2006, 2007).
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