Sentence examples for due to activating from inspiring English sources

However, during tumorigenesis there is often constitutive activation of PTKs due to activating mutations or aberrant growth factor or cytokine signaling.

EGFR inhibitors, MEK inhibitors, and BRAF inhibitors can control the growth of cancer cells by abating extra pathway activity, so effects of these drugs partially depend on their ability to control aberrant activity of the pathway due to activating oncogene mutations.

In a family of HBM cases due to activating low-density lipoprotein receptor-related protein 5 (LRP5) gene mutations, which enhance osteoblast activity, radiographs have shown widened long bones and cortices [2].

Edghill EL, Flanagan SE, Ellard S. Permanent neonatal diabetes due to activating mutations in ABCC8 and KCNJ11.

Reporter activity was enhanced by exogenous SHh ligand (p<0.005) and inhibited by the ligand-neutralizing monoclonal antibody 5E1 (p<0.0001), suggesting that Hh signaling was ligand dependent and not likely due to activating mutations within pathway components.

This pathway is often dysregulated in human cancers, frequently due to activating mutations of the KRAS, NRAS, or BRAF genes.

The Department of Health was due to activate emergency supply chain operations, with instructions to medicines suppliers to book space on ferries to ensure they are not caught up in queues from next weekend in the event of no-deal.

In the present study, the increased Ca2+ transients were mainly due to activate RyRs because caffeine may either direct or indirect inhibition of IP3Rs [23].

Phenazine and its derivatives have been widely applied as nucleic acid cleavage agents due to active oxygen activating the C H bond of the substrate.

One dilemma, however, resides in the issue if a gene is demethylated due to activation or activated due to demethylation.

The changes in physiology are believed to be due to CLA activating the nuclear transcription factor PPAR (2).