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We speculate this is due to abrogation of p53-dependent p21 induction, which leads to elimination of anti-apoptotic function of p21.
This dependence on mitochondrial function is consistent with an accepted underlying cause of cell swelling, which is the failure of energy dependent ion extrusion due to abrogation of oxidative phosphorylation during hypoxia or ischemia [2], [4].
100 ppm CO exposure attenuated neutrophil sequestration within the pulmonary vasculature as well as LPS-induced neutrophilia at 6 hours after LPS, likely due to abrogation of neutrophil mobilisation from bone marrow.
We show here for the first time that severe hypoxia induces complete antifolate resistance due to abrogation of antifolate-induced DNA damage and cell cycle arrest.
Therefore, the block at the DN3 to DN4 transition upon loss of FADD is not due to abrogation of pre-TCR signaling, but rather may involve the interpretation of the pre-TCR signals.
All anti-resorptive drugs currently used in clinical settings display reduced fracture risks due to abrogation of osteoclast functionality, which leads to lower activation frequency of new remodeling sites.
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Tumors activate HIFα either in the face of hypoxia resulting from poor vascularization or due to genetic abrogation such as VHL loss (Gordan and Simon, 2007).
Residual expression of some of the target genes may be due to incomplete abrogation of β-catenin expression (see below).
This result suggests that the lethality from the deletion of Cdk2ap1 is not due to the abrogation in the hatching process.
The large quantity of DNA damage sustained by these cells due to checkpoint abrogation results in mitotic catastrophe and subsequent cellular death from this mitosis.
This was probably due to the abrogation of the protective, reductive effect of DHFR by the MTX treatment.
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