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Some bleeding disorders are due to abnormalities of platelet function rather than to a defect in platelet number.
The former consists of a fully awake person who engages in compulsive eating at night, typically due to abnormalities of the hypothalamic-pituitary axis.
PPARγ-null mice die at midgestation (E10.5-E11.5) due to abnormalities of the placenta, characterized by small labyrinth, reduced spongiotrophoblast, and expanded giant cell layers [6], [7].
Infection remains an important cause of morbidity and mortality in diabetics, probably due to abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing.
Our data also provide additional support for the hypothesis that mitochondria accumulate in oxyphil cells due to abnormalities of the mitochondrial genome.
Firstly, the groups of George Chrousos and of Steven Lamberts defined hereditary GC resistance due to abnormalities of the GC receptor (first reviewed in [ 1, 2]).
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Familial HLH is genetic, mainly due to abnormality of perforin, MUNC13-4, syntaxin or MUNC18-2 [14].
bMan-Whitney test was applied due to abnormality of the data distribution.
Although phenolic compounds contained in LD have antidiabetic effects, some study suggested that pinitol in LD has no effect on insulin-mediated glucose disposal due to abnormality of insulin-signaling pathway in diabetes [ 18].
In SHR, GLUT4 in plasma membrane of myocytes increases with age as part of a compensation mechanism due to abnormalities characteristic of hypertensive status [ 11], and this fact suggests that GLUT4 gene expression does not have a key role in the development of insulin resistance in these animals.
For instance, knockout of the von Hippel-Lindau tumor suppressor, a peripheral membrane protein (UniProtKB AC P40337), which is also a hub in our network, causes prenatal lethality due to abnormalities in the morphology of various organs during the development and organogenesis of the embryo in mice [ 71– 71].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com