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However, in practice the depth-of-focus increases as the focal volume is focused deeper into the sample due to aberrations caused by refraction at the surface of the sample17.
The phase set degradation due to aberrations in the injector ion-optic system was simulated with allowance for multipole and fringing fields.
Electron ray tracing in these fields provided useful information on abnormal local heating of the foil due to aberrations in the beamlets.
In order to obtain measurements with small errors, the defocus should not be chosen solely to maximize contrast, since this will also cause large errors due to aberrations.
When image simulations are used to estimate errors due to aberrations, it is a common practice to use a model of an unrelaxed crystal, under the assumption that the errors caused by these aberrations are insensitive to the small difference between the unrelaxed and relaxed crystal [16 19].
Given that there were differences in MDSC infiltration following different anti-VEGF therapies, we hypothesized that this may be due to aberrations in intra-tumoral IL-1β levels.
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The phase set degradation due to aberration in the injector ion-optic system was simulated with allowance for multipole field components and fringe field effect.
Other defects in DNA single-strand break repair, for example, those due to aberration in DNA polβ are also associated with cancer (Starcevic et al, 2004).
Nonetheless, the axial sections in Fig. 3(a) are prone to a spherical like aberration due to intrinsic aberrations [ 2].
The general conclusion is that the erroneous surface strain due to imaging aberrations is much smaller in aberration-corrected images than the 5% found by Marks.
This distortion is due to the aberrations of Wolter type I optics and to the different focal surfaces (Figure 4.11) for the four mirror pairs.
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