Clipper and DEgraph declare so many pathways as significantly activated because they detect sub-graphs, which are portions of signaling circuits of dubious biological meaning.
The dubious clinical meaning and doubtful existence of normal breast-like subtype, also reflected in its heterogeneous clinical presentations of ER and HER2 phenotypes, remained unsolved and demanded further evaluations.
Because the scene was shot without sound, the warning shout from an assistant wasn't recorded, and Wexler dubbed it on afterwards, adding another if rather dubious layer of meaning to the scene.
He seems conflicted about the winning streak, proud of the accomplishment, dubious about the broader meaning, far more concerned about winning an eighth national championship.
As the private school admissions process rolls into full gear, so, too, does the parental rumor mill, churning out dubious claims about the meaning of each move a school makes as the anxious mothers and fathers of applicants seek to read the tea leaves of their child's academic future.
We have created an environment in which expectations must be met at all costs, meaning morally dubious behavior and even outright illegality is no longer off the table (see Adelphia, Tyco and Enron).
But since there are few such trucks now, the first such stations would have few customers when they opened, meaning they would seem like dubious commercial ventures.
For instance Seton Hall University in South Orange came in eighth nationally in the dubious category of "Is It Food?" -- meaning that students are not enamored of what is available in the campus cafeterias.
In the United States, many of the mortgages underlying the securities bundles that turned bad were subprime, meaning the home-buying borrowers had dubious credit histories.
