To isolate the effects of dual-task processing while minimizing effects related to task-preparatory processes, we employed a blocked event-related design in which single trials and dual trials were randomly and unpredictably intermixed for one block (mixed block) and presented in isolation of one another during other blocks (pure blocks).
16 Using the number of CSBMs as a primary endpoint, 21.2% and 16.0% of patients who received the 145 μg dose of linaclotide, and 19.4% and 21.3% of the patients who received the 290 μg dose of linaclotide, respectively, in the dual trials, met the primary endpoint.
Patients in the Hallmark-Dual trial received 60 mg of daclatasvir once a day and 100 mg of asunaprevir twice daily.
There were 100 trials per block, including 20 single task auditory trials, 20 single task visual trials, 20 null trials and 40 dual task trials, 20 trials for each SOA.
There was a behavioural training before the fMRI experiment, including two practice blocks each for single task visual trials, single task auditory trials and dual task trials (each practice block 32 trials) with feedback, followed by one block without feedback which resembled the experimental blocks in the fMRI session.
One third of single letter trials and dual task trials had target letter (5 trials per block each).
TRACER was designed as a triple versus dual antiplatelet trial in NSTEMI patients with no previous long-term outcome data supporting such aggressive strategy.
One third of trials with target letters (in total 40 dual task trials, 20 per SOA and 20 single task visual trials per session) entered the analysis of the behavioural data collected during fMRI scanning.
It is possible that subjects dedicated more attention to the tone response in dual task trials than in single auditory trials, which could account for the difference in performance between the conditions.
The major part of the fMRI analyses (all except data shown in the right panel of Figure 3 and Figure 4) was based on the other two third of nontarget trials with maximal one correct (tone) response (in total 120 dual task trials, 60 per SOA, and 60 single task visual trials per session).
