According to the dual-process theory, sensitization is the side of the pendulum that, when present, prevails at the beginning of the stimulus session and accounts for the initial transitory increase in response amplitude, whereas habituation occurs later during the course of the recording session and accounts for the delayed response decrement [6].
According to the dual-process theory, sensitization may be induced by repeated applications of a primary, or intrinsic, stimulus.
The habituation-desensitization paradigm exemplified by these animal models is in contrast to the purported habituation-sensitization dual process that has permeated previous studies of nonassociative learning.
Therefore, we believe that hydrogen sensing by Pd is attributed to the dual (chemical and electronic) sensitization mechanism.
The waxing and waning of the pungency following repeated capsaicin application is reminiscent of the sensitization-habituation dual process of nonassociative learning [ 10, 37].
In contrast to habituation and primary sensitization (the quintessential dual process of nonassociative learning), desensitization and secondary sensitization could also involve associative training by primary and secondary stimuli.
Current literature on habituation and sensitization, the classic "dual process" of nonassociative learning, gives highly incongruous accounts between varying experimental paradigms.
Levosimendan has a dual mechanism; it causes Ca2+ sensitization through binding to Troponin C and opening of ATP-dependent K+ channels in vascular smooth muscle.
Considering that these nucleotide synthesis-related genes are major determinants of fluoropyrimidine sensitivity, the dual inhibition of EGFR and HER2 TK by lapatinib appears to represent a promising strategy for the sensitization of cancer cells to fluoropyrimidines in a subset of tumors.
In habituation paradigms, early and late responses can behave differently as a result of regulation by different mechanisms; according to the dual-process theory, increasing responsiveness (sensitization) competes with decreasing responsiveness (habituation) to determine final behavioural outcomes.
We then propose a unified framework that reconciles the discrepancies between these characterizations of sensitization and the dual-process theory.
