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The ability of these dual sensitive structures to control the release of a low molecular weight drug (ibuprofen, Ibu) and a model protein (BSA) was investigated.
Herein, we develop a novel anti-cancer PDC engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel (PTX) with redox and pH dual sensitive behaviors.
In conclusion, the enzyme/pH dual sensitive nanoparticles presented in this study can serve as a promising strategy for colon-specific drug delivery against inflammatory bowel disease and other colon disorders.
Single pH-sensitive (ES) and dual sensitive (ES-Azo.pu) nanoparticles were prepared using an oil-in-water emulsion solvent evaporation method and coumarin-6 (C-6) was used as a model drug.
The enzyme/pH dual sensitive nanoparticles were designed to release a drug based on a two-fold approach which specifically aimed to target drug delivery to the inflamed colon while preventing the burst release of drugs in the stomach and small intestine.
The study is devoted to the characterization of the semi-interpenetrating polymeric network (semi-IPN) structures, prepared as dual sensitive networks, based on poly N-isopropyl acrylamide-co-diethylene glycol diacrylate) inserted into a collagen poly N-isopropylwith potentiacrylamide-co-diethylenens.
Similar(54)
These glucosamine-carrying dual-sensitive microgels may be promising carriers for targeted drug delivery to tumors.
This dual-sensitive prodrug provides a useful strategy for anti-tumor drug delivery.
These results suggest that tocopherol-based dipeptide cationic lipids with pH and reduction dual-sensitive characteristics might be promising non-viral gene delivery vectors.
These findings have shed some light on the potential NCHOSC material used to liposome-loaded microbubble gel for temperature and ultrasound dual-sensitive drug delivery.
In this case, we designed dual-sensitive nanoparticles with enhanced drug release pattern under the presence of glutathione (GSH /Hyal-1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com