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Dual responsiveness and drug size selectivity make mechanized HMSs possess potential applications in drug delivery system.
Here in this article, a facile strategy preparing smart polymers with dual responsiveness (endosomal pH and over produced H2O2) was proposed and realized by orthogonal assembly of β-CD-hydrazone-DOX and PEG-Fc.
This dual responsiveness does not allow discrimination between a possible estrogenic and a T3-agonistic action of an EDC under investigation.
Very recently, photosensitive o-nitrobenzyl methyl ester and disulfide bonds have been introduced into the main chain or at the block-junctions in conventional triblock copolymers to introduce the dual responsiveness to the non-cross-linkable micelles.
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The integration of magnetic and reduction dual-responsiveness, folate-receptor-mediated targeting functionality and fluorescence visualization into the versatile microcapsules make MSRS-CS-MCs promising nanocarriers for future biomedical applications.
The DOX-loaded nanogels displayed pH-/thermo-dual responsivenesses in drug release, which can be effectively internalized into KB cells (a human epithelial carcinoma cell line) to exert good anticancer bioactivity.
In summary, we have successfully fabricated novel AuNR@PAA/CaP yolk shell NPs which possess ultrahigh anticancer drug loading, superior photothermal conversion ability, good biocompatibility and pH/NIR dual-responsiveness.
One strategy is to design a dual responsive reversible cross-linked micellar nanocarrier, which combines the clean and efficient photo-cross-linking with the responsiveness to the acidic or reducing tumor microenvironment for on-demand drug release.
Such hydrogels with remarkable mechanical properties and dual pH-responsiveness should find applications in load-bearing soft actuators, flexible electronics, etc.
In summary, 50%FA/500% PAT has been identified as optimal for dual MMP-responsiveness and folate receptor targeting.
Combinatorial introduction of acyl, alkylsulfonyl and azobenzene (Ab) functionalities into amine-rich branched polyethylenimine produces dual-signal-responsive polymers with both temperature- and light-responsiveness in aqueous solutions.
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