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In the nanoplexes, the 3′,3″-bis-peptide-siRNA conjugate (pp-siRNA) and gemini-like cationic lipids (CLDs) were employed as dual regulators to improve their bio-behavior.
These regulators represent all known TR classes of E. coli: activators (AraC), repressors (LacI, TetR), and dual regulators (λcI) [7].
No significant difference was observed when allowing 1 or 2 mismatches for Repressors and Dual regulators.
Furthermore, the largest proportion of perfectly palindromic inverted repeats is formed from words of 3 nucleotides in length, particularly dual regulators (42%, data not shown).
This computational approach resulted in an average distribution of DNA-binding tregulatorsonal regulators in the four corynebacterial species of 73.8%% repressors, 16.4 % activators and 9.8 % dual regulators.
Most of these 57 connections, previously classified as non-predictive associations when sigma70 was part of the initial network, were associated with dual regulators such as FNR, CRP, ArcA, IHF and H-NS.
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The global transcriptional dual regulator ArcA functions as the response regulator of the two-component regulatory ArcAB system, which regulates the expression of genes involved in aerobic and anaerobic metabolism in response to oxygen availability (Iuchi and Ec 1988; Lynch and Lin 1996).
Taken together, our results establish Spt5 as a dual regulator of transcription elongation in vivo and reveal a small but diverse set of direct target genes.
Together our findings establish Spt5 as a dual regulator of transcription elongation in vivo and identify a small but diverse set of target genes critically dependent on Spt5 during development.
A TF can work as an activator, a repressor, or as a dual regulator.
Here we show that DHEA acts as a dual regulator of these two genes.
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