All fractions except for FIII-1 had dual pH optima.
The dual pH-responsive property of the prepared membrane is reversible and repeatable.
These two co-existing states resulted in the dual pH optima of the enzyme as determined experimentally.
The dual pH optima has not been reported for the proteases from L. rubellus and E. fetida.
In this study, ionoprinting has been combined for the first time with a tougher interpenetrating network polymer (IPN) hydrogel with dual pH and temperature responsiveness.
The oxidative stress amplifying nanoplatforms are composed of dual pH-sensitive PBCAE copolymer, polymeric prodrug of BCA (benzoyloxycinnamaldehyde) and heme oxygenase-1 (HO-1) inhibiting zinc protoporphyrin (ZnPP).
In this study, a dual pH- and ammonia-vapor-responsive polyimide (PI -based nanofibrous membrane with high PI -basedflux ananofibrousy was developed for oil-water separations.
As a result, star-shaped block copolymers with dual pH- and thermo-sensitivity were obtained with different aggregation characteristics corresponding to the pKa of the functionalized blocks.
Such hydrogels with remarkable mechanical properties and dual pH-responsiveness should find applications in load-bearing soft actuators, flexible electronics, etc.
Moreover, a chemotherapy drug (DOX) was loaded on it; this acquired NGO PEG DA/DOX complex exhibited a dual pH-responsiveness, showing distinctly improved cellular uptake under the tumor microenvironmental pH and augmented DOX release under lowered pH inside cell lysosomes.
