Sentence examples for dual pan from inspiring English sources

NVP-BEZ235 is a dual pan inhibitor of the PI3K/AKT/mTOR pathways at the levels of PI3K and mTOR, which inhibits growth and proliferation in MM.

The dual pan PI3K/mTOR inhibitor, NVP-BEZ235, inhibits cellular proliferation both in vitro and in vivo and is currently undergoing phase I/II clinical trials (Maira et al, 2008; Serra et al, 2008; Baumann et al, 2009).

BEZ235 is a potent dual pan class I PI3K and mTOR inhibitor that inhibits the growth of CaP (PC-3) and other malignant cells in mouse xenograft models; (3).

As a matter of fact, many of the most effective PI3K-Akt-mTOR-targeted cancer therapies owe their activity to inhibition of dual or multiple components in this pathway, such as NVP-BEZ235 (a dual pan-PI3K/mTOR inhibitor) and SF-1126 (inhibitof of all isoforms of PI3K and other PIKK family members), which are now entering into Phase I/II clinical trials [4].

PI103 is another potent dual pan-class I PI3K and mTOR inhibitor and selectively targets DNA-PK, PI3K (p110 α) and mTOR.

Novel compounds in clinical development by Novartis include the pan-PI3K inhibitor buparlisib (BKM120), the dual pan-PI3K/mTORC1/2 inhibitor BEZ235, and the selective p110α inhibitor BYL719.

NVP-BEZ235 (BEZ235) is a potent dual pan-class I PI3K and mTOR inhibitor that inhibits PI3K and mTOR kinase activity and has been used in preclinical studies in many cancers to demonstrate excellent anticancer effects.

These drugs include allosteric mTORC1 inhibitors, Akt inhibitors, inhibitors of all four class I PI3K isoforms (so-called pan-class I PI3K inhibitors), dual pan-class I PI3K and mTORC1/2 inhibitors, and, most recently, isoform-specific PI3K inhibitors.

However, no technical means currently exist to prove a long-term stability any better than that of the IPK's because the most sensitive and accurate measurements of mass are made with dual-pan balances like the BIPM's FB2 flexure-strip balance (see External links, below).

Other groups have focused on predictors of response to dual and pan-ErbB TKIs.

Single-, duand, and pan-receptor scaffold hops are also discussed.