At this moment, hundreds of millions of women and girls around the world are menstruating, and many are experiencing the dual negative impact of stigma and lack of resources.
In addition, further layers of complexity in REST-CoREST-nuclear receptor regulation and function are suggested by the recent finding that Nr2e1 participates in a dual negative transcriptional feedback loop with the microRNA, miR-9 [85], which also has similar transcriptional regulatory relationships with REST and CoREST [16], [86].
Dual negativity for COX-2 and HER-2/neu was significantly associated with control status (17 of 27 controls were dual negative, p = 0.024).
Thus, apoptosis-associated conversion of sphingomyelin into sphingosine (Fig. 4), a promoter of LMP, appears to have a dual negative effect on lysosomal membrane integrity.
Although there was 84% agreement (excluding inconclusive ICC results) between 2 methodologies, this was mostly because of the concordance of dual negative findings.
Such dual ("negative" and "positive") effects of noises might be actually exploited by realistic living organisms or cells to positively facilitate some functions.
*Based on nuclear FABP7 and EGFR immunoreactivity: dual negative as "0", nuclear FABP7-/EGFR+ as "1", nuclear FABP7+/EGFR- as "2", and dual positive as "3" NA, no IHC data available.
We examined the association of nuclear FABP7 with patient survival in relation to the EGFR expression in the 55 cases (Table 2) that had all parameters available using newly designated variables as defined in Methods: dual negative as "0", nuclear FABP7-negative/EGFR-positive as "1", nuclear FABP7-positive/EGFR-negative as "2", and dual positive as "3".
To evaluate the relationship between nuclear FABP7 and EGFR upon patient survival, new variables were used to divide patients into four groups based on the immunoreactivity of nuclear FABP7 and EGFR of their tumors: dual negative as "0", nuclear FABP7-negative/EGFR-positive as "1", nuclear FABP7-positive/EGFR-negative as "2", and dual positive as "3".
*Based on nuclear FABP7 and EGFR immunoreactivity: dual negative as "0", nuclear FABP7-/EGFR+ as "1", nuclear FABP7+/EGFR- as "2", and dual positive as "3" In our 61 GBM specimens poor survival was associated with increased nuclear FABP7 immunoreactivity as well as EGFR expression.
