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At this moment, hundreds of millions of women and girls around the world are menstruating, and many are experiencing the dual negative impact of stigma and lack of resources.
In addition, further layers of complexity in REST-CoREST-nuclear receptor regulation and function are suggested by the recent finding that Nr2e1 participates in a dual negative transcriptional feedback loop with the microRNA, miR-9 [85], which also has similar transcriptional regulatory relationships with REST and CoREST [16], [86].
Thus, apoptosis-associated conversion of sphingomyelin into sphingosine (Fig. 4), a promoter of LMP, appears to have a dual negative effect on lysosomal membrane integrity.
Although there was 84% agreement (excluding inconclusive ICC results) between 2 methodologies, this was mostly because of the concordance of dual negative findings.
Dual negativity for COX-2 and HER-2/neu was significantly associated with control status (17 of 27 controls were dual negative, p = 0.024).
Such dual ("negative" and "positive") effects of noises might be actually exploited by realistic living organisms or cells to positively facilitate some functions.
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As the economy turns around, quality bonds will face the dual negatives of a reversal in Federal Reserve policy and competition from a resurgent stock market.
7, 8 Common motifs or topologies include: (i) negative-feedback loops, which reduce transcriptional noise 9 and gene network response times 3; (ii) positive-feedback loops, made of factors that activate themselves, which can lead to bistability 10, 11 and (iii) positive-negative or dual-negative topologies that can act as toggle switches, 12, 13 providing potential memory-coding units in cells.
The proposed structure operates as a magnetic resonator that provides dual band negative permeability behavior as a result of magnetic resonance produced due to self and mutual coupling of the inclusions.
During long-term follow-up, no CIN3+ lesions developed in HPV-positive, dual-stained negative women.
Text-mining and siRNA screening led, respectively, to the identification of 288 and 96 positive modulators (including dual positive-negative modulators) of autophagy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com