Sentence examples for dual mutation from inspiring English sources

Dual mutation of the predicted AP1 site and the core abrogated the ability of Zta to interact with the XPC oligonucleotide, demonstrating that binding of Zta to the non-methylated XPC site resided with this AP1 site (Figure 7).

By cloning and sequencing BRAF exon 15, we confirmed that a dual mutation was present on a single allele and thus resulted in a BRAF V600DK601del mutant protein.

On the contrary, tumors harboring point mutations in exon 18 and dual mutation of exon 19 deletion and S768I are reported to possible response to EGFR-TKIs.

However, if selective pressures are involved, so that dual mutation enhances or restricts cell growth or survival, the value for a given gene will fall either above or below this line.

In this study, we have discovered high TAZ expression in non-small cell lung cancer (NSCLC) cells harboring dual mutation and TAZ depletion sensitized their response to EGFR-TKIs.

However, the identification of a dual mutation in genomic DNA extracted from a pool of multiple cells does not necessarily mean that the two mutations are carried by a unique allele; they may correspond to two alleles in a single tumor clone or even to two individual tumor clones.

Interestingly, some dystroglycanopathies are accompanied by eye defects (Martin, 2006) and one might speculate that this involves DG mediated energetic stress that is mimicked in the fly by dual mutations in Dg and mRpL34.

This formulation of the problem allowed us to consider the scenario in which a second drug resistance mutation occurs during the growth of a population of singly resistant mutants rather than assuming that dual mutations occur during a single replication event.

No fifth month isolates had such dual mutations.

Azole resistance is typically associated with cyp51A mutations, especially the TR34/L98H and TR46/Y121F/T289A dual mutations.

Here, we revealed that the dual mutations K130M/V131I can enhance the function of HBx in upregulating HIF-1 α.