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We reason that the prevalent dual interactions of remodelers guarantee proper transcriptional regulation.
The prevalent dual interactions of remodelers also validate our landscape since our remodeling-modification interactions are not trained on interactions of remodelers with both histone-modifying enzymes and histone residues at all.
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A good correlation (R2 = 0.524 and 0.627 for MAO-B and AA2AR, respectively) was established between docking predicted and experimental K values, which confirms that the molecular docking approach is reliable to study the mechanism of dual interaction of caffeinyl analogs with MAO-B and AA2AR.
The apparent additional structural plasticity required for the dual interaction of bH1-44 relatove to Herceptin appears to pose minimal additional energy barriers.
BiFC is used for dual interaction of proteins using different spectral characteristics and it also enables for quantitative analysis of dual protein interactions at a single cell level [5] [7].
This important dual interaction of HDL-C and the ABCA1 transporter is of great importance and recently we have learned that certain gene polymorphism of ABCA1 transporter may have a profound effect on HDL-C in addition to the well known abnormality of Tangier disease [ 11].
The checkpoint adaptor Rad9 is recruited to sites of DNA damage likely through a dual interaction of its BRCT domains with H2A-S129P and its Tudor domain with histone H3 methylated at lysine 79 (H3-K79Me) (Giannattasio et al. 2005; Javaheri et al. 2006; Toh et al. 2006; Hammet et al. 2007; Germann et al. 2011).
EBOV entry mediated by hTIM-1 results from a dual-interaction of viral GP and PS with hTIM-1 receptor.
The molecular mechanisms of these dual interactions mediated by the TRAM TIR domain are not clear.
T lymphocytes absorb APC-derived nanometric membrane vesicles, naturally-occurring exosome-like membrane vesicles (eMVs) or artificially prepared plasma membrane-derived membrane vesicles (pMVs), via dual receptor/ligand interactions of TCR/pMHC plus LFA-1/ICAM-1[13] LFA-1/ICAM-1[13] LFA-1/ICAM-1[13]
The eMV-absorption by 2C T cells was found to be mediated by specific dual receptor/ligand interactions of 2C TCR with a cognate pMHC (Ld/QL9 or Ld/p2Ca) plus LFA-1 with ICAM-1.
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