This dual dose-dependent response could be illustrated further by fine-tuning the range of serum used.
A 10-fold HS concentration range was used in the experiment illustrated in Figure 1B to illustrate this characteristic dual dose-dependence and to better highlight the decrease of turbidity associated with higher amounts of serum.
That is, in spite of the low turbidities obtained under these control conditions with boiled trypsin or boiled chymotrypsin, a dual dose-dependent response could still be discerned, exactly as seen earlier with untreated serum (Fig. 1 and Fig. 2A and B, "None" column).
In simulation results we observed an additional effect of the dual dose-dependent regulation of PIN1 expression by auxin: increase of auxin flow from the shoot results in additional auxin maxima formation at the inner root cells or at the root base.
As these two genes were only significantly inhibited upon high concentrations of TNF-α stimulation compared with the control group, we conclude that TNF-α might have a dual, dose-dependent modulatory effect on MFs at the beginning of a healing process.
Although the waiting time after the second, ip, dose of ivermectin was short, t d and long-term survival were increased for animals receiving dual doses of the drug.
AGS-499 was administered s.c. 24 and 12 h prior to i.p. injection of NMDA, and the effect of dual doses of AGS-499 on telomerase in the FB was measured by TRAP assay.
Notably, we found no significant differences in the levels of EGFP expression whether the unrelated AAV was added or not (supplementary Fig S16), proving that the double dose of dual AAV capsids administered when compared to AAV-NS does not affect dual AAV-mediated transduction.
Preliminary results on hyperdense liver lesions for the standard deviation per lesion (N=86, median 14 mm, 2 4 segmentations) have a median of 7% Vol. For lung lesions a study with dual low-dose scans was evaluated (N=95 lesions, median 8 mm).
