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Efficient transitions of OFF/ON dual contrast effects are observed by in vitro imaging and MR relaxivity measurements.
Selim et al. demonstrated the use of folic acid-conjugated magnetites as a folate-targeted dual contrast agent for nuclear imaging [20].
The goal of this study is to design, synthesize, and characterize a new target-specific dual contrast agent for MR and optical imaging.
Combinations of microbubbles (MBs) and superparamagnetic iron oxide nanoparticles (SPIONs) are used to fabricate dual contrast agents for ultrasound and MRI.
This research has demonstrated that the utilisation of these dual contrast agents and combination of two imaging techniques (MRI and fluorescent optical imaging) allowed for more accurate localisation and delineation of tumour margins, an important consideration for surgical resection of tumours (Fig. 13) [61 64].
Because it is a dual contrast agent, the distribution of NOTA-SPION MBs to the liver could also be confirmed by MRI, in which the signal of the liver was markedly decreased 2 h post injection (Figure 7C) compared with that prior to injection (Figure 7A).
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The demonstrated high fluorescence/photoacoustic dual contrasts, together with its low toxicity and excellent circulation life time, suggest that the synthesized rNGO-PEG/ICG can be a promising candidate for further translational studies on both the early diagnosis and image-guided therapy/surgery of cancer.
Autophagy is known to display a dual contrasting function in cancer cell biology.
Dual-contrast liver SPCCT imaging could help reducing radiation exposure.
To assess the feasibility of dual-contrast spectral photon-counting computed tomography (SPCCT) for liver imaging.
First, we used numerical experiments to evaluate the imaging features in dual-contrast liver SPCCT.
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