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MTR exhibits dual binding mode since it binds to histone proteins present in chromatin besides DNA [ 4].
Baumgartner, R. et al. Dual binding mode of a novel series of DHODH inhibitors.
Du, J. et al. Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants.
The model suggests that -arisugacin A is a dual binding site covalent inhibitor of AChE.
Enzyme kinetic and molecular docking studies have confirmed their dual binding affinity and mixed type inhibition.
Secondly, we generated active-exosite peptides with structurally confirmed dual binding mode and improved potency.
The mixed type inhibition of compound 4d further confirmed their dual binding nature in kinetic studies.
Baumgartner R, Walloschek M, Kralik M, Gotschlich A, Tasler S, Mies J, et al. Dual binding mode of a novel series of DHODH inhibitors.
The enhancing effects of MAL in TV infectivity in the light of the dual binding of MAL to both cells and TV are unique.
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A series of indolinone-based compounds bearing benzylpyridinium moiety was designed as dual-binding inhibitors of acetylcholinesterase (AChE).
These findings suggested that Bis-Mep might be a promising dual-binding AChE inhibitor for potential AD therapeutics.
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