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In this perspective, we describe the first generation of POE, such as dual acquisition MAS (or DUMAS) methods, and then illustrate the evolution of these experiments into MEIOSIS, a method that enables the simultaneous acquisition of multiple 2D and 3D spectra.
The phantom was scanned for 60 min (dual acquisition).
Although the accuracy of Tc-99m measurement for dual acquisition was less than that of I-123 measurement (Fig. 7), the FiveEW method had higher quantitative accuracy for simultaneous dual acquisition.
They were then injected with I-123 N-isopropyl-4-iodoamphetamine hydrochloride (IMP) and scanned again (dual acquisition).
The scanned projection data for the dual acquisition were corrected for scatter by using the FiveEW and FiveEW-woDR methods.
Then, I-123 (77 MBq) was additionally injected into the phantom, and the phantom was scanned again for 21 min (dual acquisition).
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The whole brain counts of the CBV images for single and dual acquisitions were compared, and the intra-class correlation coefficients between the single- and dual-acquisition images were calculated.
In the volunteer study, the PD between the single and dual acquisitions was 4.5 ± 3.4 %.
The counts of the Tc-99m images for the single and dual acquisitions were compared.
The differences in the six-compartment phantom experiment (Table 5) represent count measurement reproducibility between single and dual acquisitions.
In the cylindrical phantom experiments, the percentage difference (PD) between the single and dual acquisitions was 5.7 ± 4.0 % (mean ± standard deviation).
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