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The total acquisition time of DTI was 4 min. Test retest studies showed that measurement reproducibility of the DTI protocol yielded intraclass correlation coefficients (ICC) of 0.8 and higher in the vast majority of brain regions.
We evaluated the validity of wild bootstrap utilizing numerical simulations with different combinations of DTI protocol parameters and wild bootstrap experimental designs, and quantitatively compared estimates of uncertainties from wild bootstrapping with those from Monte Carlo simulations.
The purpose here was to develop a simple DTI protocol using readily available standard single-shot EPI at 3T, capable of yielding much higher spatial resolution images (1 x 1 x 1 mm3) of the human hippocampus in a 'clinically feasible' scan time of ~6 min.
31 age-matched healthy controls underwent the same DTI protocol.
The DTI protocol described below was the same regardless of the fMRI task.
It also implies that DTI protocol is suitable to generate fingerprints for ischemic stroke.
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Our results demonstrate that a wild bootstrap implementation using at least 1000 wild bootstrap iterations with a type II or type III heteroskedasticity consistent covariance matrix estimator provides robust evaluations of most DTI protocols.
All patients underwent pre-operative MRI, surgery and subsequent post-operative MRI follow-ups at 1.5T including T1w, T2w sequences and a DTI-protocol.
We conclude that it is advisable to use a DTI-protocol instead of standard diffusion-weighted imaging for neuro-oncological exams.
The genetic and MRI analysis protocols used in ENIGMA2, including quality control steps, are available online, at http://enigma.ini.usc.edu/ongoing/gwasma-of-subcortical-structures/ and the DTI analysis protocols are available at http://enigma.ini.usc.edu/ongoing/dti-working-group/.
ENIGMA-DTI is a Working Group developing a harmonized protocol for analyzing DTI data for GWAS meta-analysis (Kochunov et al. 2012).
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