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ε4+ and ε4− patients did not differ on any MRI or DTI measure.
Separate models were created to examine each DTI measure.
In an exploratory step, we also tested for a DTI measure – age interaction and a DTI measure – baseline MADRS interaction effect on remission.
In models controlling for baseline MADRS score, age, sex, and CIRS score, no DTI measure was significantly associated with time to remission (data not shown).
Independent variables included the DTI measure, baseline depression severity measured with the MADRS, age, sex, medical comorbidity measured using the CIRS, and a variable accounting for which assessment period was being evaluated (baseline, 2-, 4-, 6-, 8- or 12-week).
To detect the specific location along each bundle where the DTI measure is associated with the psychopathology, the same partial correlation analysis was performed on every point of each bundle.
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In the present study, the voxels were selected based on anatomical rather than functional differences in DTI measures between groups because the DTI scan did not measure functional activation, and there was no behavioral task or behavioral activation involved with the selection of voxels for subsequent behavioral regression analysis.
A large number of DTI and MRS studies have been performed that have investigated differences in DTI measures and brain metabolites in the setting of ALS including a number of studies that have included both DTI and MRS acquisitions.
DTI measures neither correlated with the ImPACT nor SCAT2.
DTI measures the molecular diffusion of water along neural pathways.
Although the PA subjects showed no difference in DTI measures relative to the controls, the extensive correlations between the former heroin consumption and the DTI measures were noted.
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