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The DTI analysis software TIFT was used for DTI data processing.
Fractional anisotropy (FA) is a commonly used parameter in DTI analysis, although properties of DTI/FA in analyzing brain modifications in PD have been poorly profiled.
In contrast, none of these examples of fiber crossing and complex structure was identified by DTI analysis of the same data sets.
DTI analysis did not reveal any significant differences in migraineurs without aura comparing with healthy controls.
These findings suggest that the canine model parallels MPS in humans, and further indicates that quantitative DTI analysis of such animals may be suitable for future study of disease progression and therapeutic response in MPS.
On the other hand, Lope-Piedrafita et al. published a longitudinal diffusion tensor imaging (DTI) analysis of C6 glioma rats showing high FA values in the brain tissue surrounding the tumour due the great glioma proliferation rate [44].
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An increasing number of quantitative methods were introduced to DTI data analysis, such as voxel-based analysis (VBA) [ 3] and tract-based spatial statistics (TBSS) [ 4, 5].
Further details of DTI data analysis are given in the Supplementary material.
DTI tractography analysis revealed that the previously misplaced DBS electrodes were touching the median polysynaptic pain system (MPNS) (Fig. 1a-c, blue arrows).
We found no significant association between neuropsychological testing and the results of DTI-TBSS analysis.
For this reason, we limited our DTI-TBSS analysis to the white matter skeleton.
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