Exact(17)
According to the national TB control program, DST should be performed on patients taking category II treatment who remain smear positive after the fourth month of treatment.[25] However, this strategy is a necessary balance between operational considerations and early diagnosis, and will provide delayed results for many cases with primary or acquired drug resistance.
DST should be performed at the start of therapy for all previously treated patients.
Second-line DST should be performed to confirm the drug resistance pattern and to guide the correct choice of treatment.
Furthermore, we recommend that routine DST should be performed on MTB isolates obtained from children with culture-confirmed TB in these high-burdened settings.
As many nursing home residents showed a substantial cognitive decline, the DST should be used only as an indicator and not as an objective evaluation instrument.
Ideally, routine drug susceptibility testing (DST) should be conducted before initiation of treatment in all patients with TB, but this is not achievable in most high-prevalence countries because of poor access to bacterial culture and DST tools.
Similar(43)
The DST rate should be set at 3%, which achieves an appropriate balance between revenues generated by the tax and accounting for the differential DST impact for businesses with different profit margins.
To protect small companies and start-ups compared to bigger companies, the DST rate should be 3% over the revenues between EUR 25 000 000 and EUR 100 000 000 and a 5% over the revenues above EUR 100 000.
However, phenotypic culture-based DST should still be used for the downstream investigation of patients who have susceptible MTBDR sl results.
To guide therapy, both species-level identification and DST of NTM isolates should be performed.
As soon as the results from the culture DST are available, the treatment regimen should be individualised according to the DST result to fluoroquinolones and SLIDs (the DST to the other SLD should be carefully evaluated because the clinical reliability of this DST is very poor).
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