Exact(8)
However, we expected research studies evaluating the accuracy of molecular DSTs, such as the MTBDR sl assay, to almost always include phenotypic DST as a reference standard.
One (Kiet 2010) of the eight studies that performed indirect testing for XDR-TB and used cultured-based DST as a reference standard used ofloxacin and kanamycin.
figure 18 shows forest plots of MTBDR sl sensitivity and specificity for ofloxacin (Ofl) and moxifloxacin (Mx) resistance detection when performed indirectly and using phenotypic culture-based DST as a reference standard.
We show forest plots of MTBDR sl sensitivity and specificity for XDR-TB for three studies (664 participants) that used phenotypic culture-based DST as a reference standard in 14.
In figure 14 we present forest plots of MTBDR sl sensitivity and specificity for XDR-TB for eight studies (880 participants) that used phenotypic culture-based DST as a reference standard.
We present forest plots of MTBDR sl sensitivity and specificity when performed indirectly for the detection of resistance to SLIDs for 14 studies (1637 participants) that used phenotypic culture-based DST as a reference standard in 8.
In 6 we show forest plots of MTBDR sl sensitivity and specificity when performed directly for the detection of resistance to FQs for seven studies (1033 participants) that used phenotypic culture-based DST as a reference standard.
There was no evidence of a statistically significant difference in MTBDR sl accuracy between indirect and direct testing and using culture-based DST as a reference standard when the test was performed in different populations (indirect comparison, P = 0.549).
Related(1)
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