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The system development of a DSS for water resources management based on the DSS model has demonstrated both efficiency of the development process and effectiveness of the system developed.
Further, the therapeutic efficacies of UroA/UAS03 were also examined in a chronic DSS model, where mice were given 4 cycles of 2% DSS in drinking water for 7 days with an interval of 14 days in each cycle on regular water (Fig. 6a).
DSS model of induced colitis was used because of its rapid effect, simplicity, reproducibility and controllability [27].
A simple DSS model unambiguously confirmed the protective effect of CD97 overexpression in intestinal cells (fig. 3a).
These CD97 Tg mice were examined in the azoxymethane (AOM /dextran sodium sulfate (DSS) model for colitis-associated tumorigenesis.
Furthermore, we characterized the effects of these strains in vivo using a Dextran sulphate sodium (DSS) model of colitis.
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We utilized the AOM-DSS model for colitis-associated colorectal cancer (CAC) in wild type (WT) and TLR2−/− mice.
However, that study did not use the AOM-DSS model but used a different experimental model of tumorgenesis, the ApcMin/+ model [23].
They also found reduced numbers of tumors in TLR4−/− mice using the same AOM-DSS model we used in the current study.
We have demonstrated that TLR4-/ mice are protected against development of colitis-associated neoplasia in the AOM-DSS model [ 28].
To explore colorectal tumorigenesis in vivo, the widely used AOM-DSS model of colitis-associated colorectal tumorigenesis was employed [ 10, 11].
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