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If this were being done over a phone line or even DSL, I may have concerns.
Note that in the univariate regression of one phenotype on a DSL, the effect of the DSL can be larger than simulated when the DSL is in high LD with other DSL (i.e. the effect is augmented because of the correlation of the DSL to other DSL in the same LD block: see Supplementary Information Simulations).
Genetic data included a small gene (10 SNPs) or a larger gene (60 SNPs, assuming equal coverage) with varying numbers of disease-susceptibility loci (DSL, i.e. a SNP that is causally related to one or more phenotypes), and LD blocks.
Similar(57)
One possible explanation for this phenomenon is that many of the genetic associations that are detected by GWAS are caused by multiple rare DSLs, i.e. minor allele frequency of <1%, that are in proximity to one of the GWAS-SNPs (Goldstein, 2009; Manolio et al., 2009).
This characteristic is shared by the other scientific DSLs that I am aware of.
Significant research efforts have been spent on DSM to increase the data rates in DSL access networks, i.e., rate-adaptive DSM.
We can summarize that the price of greening is very small for practical DSL access networks, i.e., much better than linear.
We found that DSL and RCA I blotted PrPSc in all samples.
We next used DSL and RCA I to probe guanidinium protocol-purified PrPSc.
In agreement with that, DSL and RCA I were previously reported to bind PrP in ELISAs [16], [17].
These data further confirm that DSL and RCA I recognize specifically PrPSc subpopulations and not other copurifying host glycoproteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com