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The dry coated tablet consists in a drug‐containing core, coated by a hydrophilic erodible polymer which is responsible for a lag phase in the onset of pulsatile release.
The results showed that a certain lag time before the drug released generally due to the erosion of the dry coated layer.
Especially, the dry coated samples present a good tribological behaviour, whereas the wear mechanisms are different between APS and laser cladding coated samples.
In this investigation a novel oral pulsatile drug delivery system based on a core-in-cup dry coated tablet, where the core tablet surrounded on the bottom and circumference wall with inactive material, is proposed.
Using a material sparing high-intensity vibrational mixer, Avciel PH-105 is dry coated with 1 wt% Aerosil 200, selected due to its relatively higher dispersive surface energy and lower particle size amongst other silica choices.
Dry coated drug powders were characterized by AOR, particle size as a function of dispersion pressure, particle size distribution, conditioned bulk density (CBD), Carr index (CI), flow function coefficient (FFC), cohesion coefficient using different instruments, including a shear cell in the Freeman FT4 powder rheometer, and Hansen flowability index.
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The acetolyzed grains were dehydrated through an ethanol series, critical point dried, coated with gold, and examined with a Hitachi SM 2400 scanning electron microscope.
Dehydrated lenses were critical point dried, coated with gold particles and examined in SEM as described previously [ 19].
Specimens were fixed, washed in acetone, critical point dried, coated with gold by a sputter coater, and observed under scanning electron microscope (SEM) fitted with a lanthanum hexaboride cathode using an accelerating voltage of 10 kV.
At 1 week after DPD withdrawal, cells were washed with PBS, then fixed with 2% glutaraldehyde in PBS then post-fixed with 1% OsO4 in PBS, dehydrated in ethanol, dried, coated with gold and examined in a field emission SEM JSM-6500FF, Japan Japan).
Ethylcellulose (EC) of varying particle sizes has been used as an outer coating layer to design a novel dry-coated tablet with time-controlled drug release.
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