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Following the chronic administration of moderate doses of antipsychotic drugs, tolerance to the effects of a haloperidol challenge dose is generally seen in the striatum and olfactory tubercle but not in the frontal cortex6 8.
By contrast, oversedation promotes drugs tolerance and withdrawal leading to a delayed recovery.
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And so we get drug tolerance.
Gomez, J.E. & McKinney, J.D.M. tuberculosis persistence, latency, and drug tolerance.
Drug tolerance is an acute defence response preceding a fully drug-resistant state and tumour relapse; however, there are few therapeutic agents targeting drug tolerance in the clinic.
Current treatments are suboptimal because of poor drug tolerance and significant failure rates.
Liau, B. B. et al. Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance.
During this time, the patients' drug tolerance increases, leading them to find different ways of acquiring drugs.
Smith, M. P. et al. Inhibiting drivers of non-mutational drug tolerance is a salvage strategy for targeted melanoma therapy.
Finally, pretreatment with a miR-147b inhibitor delays osimertinib-associated drug tolerance in patient-derived 3D structures.
The preceding paper presented a model of drug tolerance and dependence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com